Associate Scientists, CAR-T Immunology

company overview

Vor BioPharma is a preclinical biotechnology company developing a new approach to cancer immunotherapy with a focus on broadening the applicability and overcoming key challenges of engineered cell therapies. Engineered cell therapy works by modifying the body’s own immune cells so that they recognize and kill cancer cells by targeting markers on the cells’ surface. To date, successful engineered cell therapy has been largely limited to patients with advanced B-cell malignancies. In these patients, the engineered immune cells target markers that are present on all B-cells, both healthy and cancerous. While the body can safely function without B-cells, using similar approaches to treat other cancers—which would involve targeting cells necessary for survival—remains elusive. Vor BioPharma is developing a new approach that is designed to overcome key barriers that limit current modalities. Vor BioPharma is a PureTech Health (LSE: PRTC) company.

Position description / responsibilities

Experience in cell biology is required for this role with preference given to candidates with demonstrated experience in immunology/cancer immunology, focusing on CAR-T cells. The successful candidate will have deep scientific curiosity, excellent oral and written communication skills, work well independently and as part of a collaborative team, and be able to work on several projects simultaneously. With appropriate supervision, the role includes planning, designing, developing methodologies and executing projects utilizing good scientific judgment. The position is a hands-on, laboratory based role.

key areas of responsibilities

  • Design, plan, and execute cell based assays and troubleshoot existing protocols with guidance
  • Perform high quality and well controlled immunological assays with human and animal primary immune cells including cell stimulation, cytotoxicity assays, cytokine analysis, and flow cytometry with minimal supervision
  • Expansion and maintenance of gene modified immune cell cultures, such as CAR-T cells
  • Generate and analyze multi-parameters data sets using appropriate analytic programs, participate in drafting presentations
  • Maintain a clear, detailed laboratory notebook to document all experiments and findings
  • Comply with laboratory safety practices

QUALIFICATIONS

  • Bachelor’s or Master’s Degree in cell biology, immunology, cancer biology, cancer immunology or related discipline is required
  •  Bachelor’s Degree with 3+ years or Master’s Degree with 1+ years of laboratory experience in an academic or industry setting
  • Experience in mammalian cell culture, isolation, culture, and characterization of primary human immune cells
  • Hands-on experience with immunological assays (CAR-T cell activation, proliferation assays, cytotoxicity assays, cytokine analysis by FACS and ELISA, and multiplex assays)
  • Experience with multiparameter flow cytometry, RT-PCR, RNA preparation, viral transduction, mammalian cell transfection, and western blotting
  • Experience with FlowJo, Graphpad Prism, Microsoft Excel and PowerPoint
  • Possess a thorough knowledge of experimental design and underlying scientific principles
  • Excellent organizational, record keeping, oral and written communication skills
  • Understanding of BSL requirements
  • Strong problem-solving skills and the ability to work independently in startup environment
  • Immediate availability